Here is an improvement in the luminescent technology used to image the position of organic molecules in living cells which is an improvement only in part because it has now gone multicolor:

http://phys.org/news/2015-04-illuminated-real-time-multicolor-imaging-luminescent.html

So far, not a big improvement I guess, but any improvement in such imaging technology has to be good news for the very important research into biochemistry of living cells.