The Greco Defence arises after 1.e4 e5 2.Nf3 Qf6. ECO code: C40.

Named after Gioachino Greco (1600–1634). Black develops the queen to f6, defending e5 but blocking the g8-knight. After 3.Nc3 or 3.d4, White obtains a significant advantage in development. The defence is considered inferior.